Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates
Article
[키워드] absence
activated
Activation
aggregate
aggregates
analysed
antiviral immunity
Blood
blood cell
CD107a
CD62P
Cell
cells
changes in
chemokines
Cohort
correlated
COVID-19
COVID-19 disease
COVID-19 patient
cytokine
Cytokines
Cytometry
cytotoxicity
discharged
disease pathology
early stage
Ex vivo
Features
flow cytometry
form
Frequency
gene signature
hospital
hospitalised
hospitalised COVID-19 patient
ICU
ICU patient
IFN-γ
IL-15
in vitro
increased expression
Infection
innate immune response
intensive care unit
killing
majority
natural
Neutrophils
NK cell
NK cells
Patient
patients
phenotype
phenotyped
plasma
Platelet
platelet aggregates.
Platelets
Post-COVID-19 patients
quantified
SARS-CoV-2
scRNA-seq
severe COVID-19 disease
severe symptoms
Single-cell RNA-sequencing
Stage
subset
Symptom
Symptoms
target cells
the timing
TNF-α
viral infections
were measured
while
[DOI] 10.3389/fimmu.2022.861251 PMC 바로가기
[DOI] 10.3389/fimmu.2022.861251 PMC 바로가기